Fracture risk after the diagnosis of parkinson's disease : Influence of concomitant dementia
Identifieur interne : 003658 ( Main/Exploration ); précédent : 003657; suivant : 003659Fracture risk after the diagnosis of parkinson's disease : Influence of concomitant dementia
Auteurs : L. Joseph Iii Melton [États-Unis] ; Cynthia L. Leibson [États-Unis] ; Sara J. Achenbach [États-Unis] ; James H. Bower [États-Unis] ; Demetrius M. Maraganore [États-Unis] ; Ann L. Oberg [États-Unis] ; Walter A. Rocca [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In an inception cohort of 196 Olmsted County, Minnesota, residents with Parkinson's disease (PD) first recognized in 1976 to 1995, we tested whether the increased risk of bone fractures is associated with concomitant dementia. Using the data resources of the Rochester Epidemiology Project, information about PD, dementia, other clinical risk factors for fracture and fracture events was obtained from review of complete inpatient and outpatient medical records spanning each subject's residence in the community. Compared to an equal number of age- and sex-matched non-PD referent subjects from the community, PD patients were at a 2.2-fold increased risk of fractures generally and a 3.2-fold greater risk of hip fractures specifically. Adjusting for age, the independent predictors of overall fracture risk in the PD subjects included female sex (hazard ratio [HR] 1.6; 95% confidence interval [CI], 1.1-2.3), dementia (HR, 1.6; 95% CI, 1.1-2.4) and chronic depression, which was associated with a reduced risk (HR, 0.4; 95% CI, 0.2-0.8). Hip fractures were predicted by dementia (HR, 2.2; 95% CI, 1.2-4.1). The increased fracture risk in patients with PD is not entirely explained by concomitant dementia, and additional study is needed to determine the relative contributions to fracture risk of falls versus bone loss in these patients.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001A08
- to stream PascalFrancis, to step Curation: 001313
- to stream PascalFrancis, to step Checkpoint: 001A94
- to stream Main, to step Merge: 004B89
- to stream Main, to step Curation: 003658
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Fracture risk after the diagnosis of parkinson's disease : Influence of concomitant dementia</title><author><name sortKey="Melton, L Joseph Iii" sort="Melton, L Joseph Iii" uniqKey="Melton L" first="L. Joseph Iii" last="Melton">L. Joseph Iii Melton</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Leibson, Cynthia L" sort="Leibson, Cynthia L" uniqKey="Leibson C" first="Cynthia L." last="Leibson">Cynthia L. Leibson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Achenbach, Sara J" sort="Achenbach, Sara J" uniqKey="Achenbach S" first="Sara J." last="Achenbach">Sara J. Achenbach</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L." last="Oberg">Ann L. Oberg</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0518088</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0518088 INIST</idno><idno type="RBID">Pascal:06-0518088</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A08</idno><idno type="wicri:Area/PascalFrancis/Curation">001313</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001A94</idno><idno type="wicri:doubleKey">0885-3185:2006:Melton L:fracture:risk:after</idno><idno type="wicri:Area/Main/Merge">004B89</idno><idno type="wicri:Area/Main/Curation">003658</idno><idno type="wicri:Area/Main/Exploration">003658</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Fracture risk after the diagnosis of parkinson's disease : Influence of concomitant dementia</title><author><name sortKey="Melton, L Joseph Iii" sort="Melton, L Joseph Iii" uniqKey="Melton L" first="L. Joseph Iii" last="Melton">L. Joseph Iii Melton</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Leibson, Cynthia L" sort="Leibson, Cynthia L" uniqKey="Leibson C" first="Cynthia L." last="Leibson">Cynthia L. Leibson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Achenbach, Sara J" sort="Achenbach, Sara J" uniqKey="Achenbach S" first="Sara J." last="Achenbach">Sara J. Achenbach</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L." last="Oberg">Ann L. Oberg</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1><s2>Rochester, Minnesota</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Diagnosis</term><term>Epidemiology</term><term>Fracture</term><term>Hip</term><term>Nervous system diseases</term><term>Osteoporosis</term><term>Parkinson disease</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Fracture</term><term>Parkinson maladie</term><term>Démence</term><term>Ostéoporose</term><term>Facteur risque</term><term>Diagnostic</term><term>Epidémiologie</term><term>Hanche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In an inception cohort of 196 Olmsted County, Minnesota, residents with Parkinson's disease (PD) first recognized in 1976 to 1995, we tested whether the increased risk of bone fractures is associated with concomitant dementia. Using the data resources of the Rochester Epidemiology Project, information about PD, dementia, other clinical risk factors for fracture and fracture events was obtained from review of complete inpatient and outpatient medical records spanning each subject's residence in the community. Compared to an equal number of age- and sex-matched non-PD referent subjects from the community, PD patients were at a 2.2-fold increased risk of fractures generally and a 3.2-fold greater risk of hip fractures specifically. Adjusting for age, the independent predictors of overall fracture risk in the PD subjects included female sex (hazard ratio [HR] 1.6; 95% confidence interval [CI], 1.1-2.3), dementia (HR, 1.6; 95% CI, 1.1-2.4) and chronic depression, which was associated with a reduced risk (HR, 0.4; 95% CI, 0.2-0.8). Hip fractures were predicted by dementia (HR, 2.2; 95% CI, 1.2-4.1). The increased fracture risk in patients with PD is not entirely explained by concomitant dementia, and additional study is needed to determine the relative contributions to fracture risk of falls versus bone loss in these patients.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Melton, L Joseph Iii" sort="Melton, L Joseph Iii" uniqKey="Melton L" first="L. Joseph Iii" last="Melton">L. Joseph Iii Melton</name></region><name sortKey="Achenbach, Sara J" sort="Achenbach, Sara J" uniqKey="Achenbach S" first="Sara J." last="Achenbach">Sara J. Achenbach</name><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><name sortKey="Leibson, Cynthia L" sort="Leibson, Cynthia L" uniqKey="Leibson C" first="Cynthia L." last="Leibson">Cynthia L. Leibson</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Oberg, Ann L" sort="Oberg, Ann L" uniqKey="Oberg A" first="Ann L." last="Oberg">Ann L. Oberg</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003658 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003658 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:06-0518088
|texte= Fracture risk after the diagnosis of parkinson's disease : Influence of concomitant dementia
}}
| This area was generated with Dilib version V0.6.23. |  |